In Silico Analysis and Experimental Validation of Active Compounds from Cichorium intybus L. Ameliorating Liver Injury

This study aimed at investigating the possible mechanisms of hepatic protective activity of Cichorium intybus L. (chicory) in acute liver injury. Pathological observation, reactive oxygen species (ROS) detection and measurements of biochemical indexes on mouse models proved hepatic protective effect of Cichorium intybus L. Identification of active compounds in Cichorium intybus L. was executed through several methods including ultra performance liquid chromatography/time of flight mass spectrometry (UPLC-TOF-MS). Similarity ensemble approach (SEA) docking, molecular modeling, molecular docking, and molecular dynamics (MD) simulation were applied in this study to explore possible mechanisms of the hepato-protective potential of Cichorium intybus L. We then analyzed the chemical composition of Cichorium intybus L., and found their key targets. Furthermore, in vitro cytological examination and western blot were used for validating the efficacy of the selected compounds. In silico analysis and western blot together demonstrated that selected compound 10 in Cichorium intybus L. targeted Akt-1 in hepatocytes. Besides, compound 13 targeted both caspase-1 and Akt-1. These small compounds may ameliorate liver injury by acting on their targets, which are related to apoptosis or autophagy. The conclusions above may shed light on the complex molecular mechanisms of Cichorium intybus L. acting on hepatocytes and ameliorating liver injury.     

基于SoC的多轴驱控一体化平台设计

随着FPGA技术和电力电机技术的发展,FPGA+ARM的集成方式已经成为FPGA的发展方向.针对一体化多轴运动控制与驱动的特点,选用了集成双核ARM CPU与FPGA结合的Xilinx Zynq-7020全可编程System-on-chip(SoC)作为硬件平台,一个ARM CPU完成多轴的位置环、速度环和电流环的算法以及多轴轨迹生成,能同时完成伺服高级算法如谐振等,另一个ARM CPU完成交互功能,发挥FPGA高速运算的功能,完成6轴电流环流水线控制以及双采样双更新电流环算法.提高了系统整体带宽,实现多轴ns级同步精度以实现更精确的位置轨迹,驱控一体内部数据通过共享内存以及高速内部总线的方式进行交换,其传输速度更快、传输信息更加丰富.     

500 kV 开关弹簧机构支架螺栓断裂的原因分析及处理

HPL500B2型弹簧机构支架(BA)螺栓断裂可能导致开关分合闸失败,对其原因进行分析,发现BA螺栓由于预紧固力矩过大,接近其扭断力矩,使得作用在BA螺栓上的力偏高,BA螺栓安全系数仅为12%,安全系数较低。列出BA螺栓更换步骤及注意事项,并详细介绍分闸、合闸弹簧调整步骤,为类似事件的处理提供参考。     

固废制备微晶泡沫玻璃的研究进展

为实现固体废弃物的高值化利用，从微晶泡沫玻璃的制备机理、工艺流程及温度制度等方面分析了工业固体废弃物制备微晶泡沫玻璃的可行性，重点论述了金属矿尾矿、赤泥、高炉矿渣、煤矸石、粉煤灰等固体废弃物制备微晶泡沫玻璃的国内外研究进展，并对微晶泡沫玻璃的研究和发展趋势进行了展望。     

中国无机盐工业发展现状及展望

建国70 a以来中国无机盐工业发展迅猛,取得了巨大成就,中国已成为世界上最大的无机盐生产、出口和消费国。分析了中国无机盐工业生产现状和进出口情况,指出行业存在大宗产品产能过剩、产品精细化率偏低、产业集中度和资源配置率偏低、矿产资源保障能力不足、节能减排任务重、自主创新能力弱等问题,并提出未来发展建议及发展方向。新能源用无机材料、无机粉体功能材料、5G通迅用无机材料、电子化学品和电镀化学品等专用化学品将是未来无机盐工业发展的热点。随着产业链现代化水平的不断提升,将会逐渐实现行业规模化、绿色发展与安全生产。